WELCOME TO THE HOMEPAGE OF Dr. D.Sriram

Recently Shifted to BITS-Pilani, Hyderabad Campus

 

 

Mailing Address:

Dr. D. SRIRAM

Assistant Professor, Pharmacy Group

Faculty-in-Charge, Educational Development Division

Birla Institute of Technology & Science-Pilani, Hyderabad Campus

Jawahar Nagar, Shameerpet mandal, R.R. District

Hyderabad-500078, INDIA

Telephone: +91-9010534101 (O)

 Email: dsriram@bits-pilani.ac.in; drdsriram@yahoo.com

 

 

 

Educational Qualifications:

 

Degree

University

Year

Subjects

Remarks

B.Pharm

The Tamilnadu Dr. M.G.R. Medical University, Chennai, India

1994

Pharmaceutical Sciences

Gold medalist

M.Pharm

Banaras Hindu University, Varanasi, India

1997

Medicinal Chemistry

 

Ph.D.

Banaras Hindu University, Varanasi, India

2000

Medicinal Chemistry

In a record period of 2 Years

 

Professional Recognition, Awards, Fellowships Received:

  1. Recipient of "YOUNG PHARMACY TEACHER OF THE YEAR 2006" awarded by the Association of Pharmacy Teachers of India.

  2. Editorial Advisory Board Member of the journal, "Recent Patents on Anti-infective Drug Discovery" published by Bentham Science Publishers (USA & The Netherlands).

  3. Best Paper in Poster presentation was awarded in the 12th APTI national Convention held in October 25-27, 2007 at Chandigarh.

  4. Life Member of Association of Pharmacy Teachers of India.

  5. Biographical profile included in the prestigious registry of the 6th edition of “Marquis Who’s Who in Science and Engineering”, 2002-2003 and regularly updated.

  6. Member, Canadian Society of Pharmaceutical Sciences.

  7. Life member, Association of Microbiologist of India.

  8. Recipient of “Sevaratna” Dr. R.Venkatesalu Gold Medal for securing First rank in B.Pharm of The Tamilnadu Dr. M.G.R. Medical University.

  9.  Recipient of First Prize award in Tamilnadu State for B.Pharmacy awarded by The Tamilnadu Pharmacy Council, Chennai.

  10.  Awarded Junior Fellowship by the UGC during the period 1995-1997.

  11.  Awarded Senior Research Fellowship by the UGC during the period 1998-1999.

 

    Details of Professional Experience:

            Involved in Research since 1996

           Involved in Teaching since 1997

    Details of employment (past & present)

                1.      Served as Lecturer at S.B. College of Pharmacy, Sivakasi, Tamilnadu, India, for 10 months in 1997.

              2.      Served as Principal of S.B. College of Pharmacy, Sivakasi, Tamilnadu, India, for 8 months in 2000.

              3.      Serving Birla Institute of Technology & Science, Pilani, Rajasthan, India, as Lecturer since Aug    2000

               and as Assistant    Professor since Feb 2005.

       4.     Transferred to BITS-Pilani, Hyderabad campus, as Assistant Professor from June 2008.

 

    Research Activities:

    Research Area:

HIV is the most significant risk factor for many opportunistic infections like fungal, tuberculosis, etc. The intense media coverage of AIDS puts the public on an emotional roller caster, and inflated promises are engendered by each success. For the moment drugs acting as both HIV-reverse transcriptase inhibitors along with antimicrobial properties are one of the brightest hope. My research focuses in drug design of a novel anti-HIV agent with broad spectrum of chemotherapeutic properties that include anti-tubercular, anti-fungal, anti-HCV, and antibacterial properties. The research efforts of Dr. D. Sriram combine synthetic organic chemistry with computational, biochemical, and molecular biological tools in an interdisciplinary approach to designing drugs.

 

Life Cycle of HIV Infection

Click Here to view the HIV Life Cycle in Flash animation

Developed by John Hopkin's AIDS service

 

 

Anti-tuberculosis drug discovery and development

 

Infection with the intracellular pathogens Mycobacterium sp. can lead to death in animals and humans. In the case of tuberculosis, current epidemiological evidence suggests that one-third of the world's population are infected with M. tuberculosis, that 8 million new cases emerge annually and that 3 million deaths per year are directly attributable to infection with the bacillus. New infection, as well as reactivation of latent tuberculosis, is particularly prevalent in individuals with compromised immune systems, such as those that are HIV positive. In addition, the emergence of drug-resistant strains of M. tuberculosis has led to increased pressure on current chemotherapy regimes. We are using both natural products chemistry and rational synthesis as models for the discovery of new anti-tuberculosis agents. To date we have identified several classes of compounds that exhibit useful potency (MIC < 1 μg/mL) towards both wild-type and drug resistant strains of M. tuberculosis. We are currently preparing new analogues in an effort to develop more potent derivatives with improved pharmacokinetic properties. Working with collaborators, we are investigating the possible mechanism(s) of action of these compounds by utilising whole genome DNA microarray analysis.

        Drug Discovery, Design and Synthesis of

1.Anti-tubercular drugs (MTB Enzyme inhibitors, Isocitrate Lyase inhibitors, Quinolones & Prodrugs)     

2. Anti-HIV agents (NNRTIs, & Anti-HIV Prodrugs)

 

         Collaborative Research Scientist at

  1. TAACF, Southern Research Institute, Alabama, USA.

  2. National Institute of Health, Bethesda, USA.

  3. Indian Institute of Science, Bangalore, India.

  4. National Institute of Mental Health and Neurosciences, Bangalore, India.

  5. National Institute of AIDS, USA.

  6. Central Drug Research Institute, Lucknow, India

 

 

Research funding Received

 

Grant agency

Title of the project

 Duration Amount
UNIVERSITY GRANTS COMMISSION (UGC), NEW DELHI, INDIA INVESTIGATION ON STRUCTURE-ACTIVITY RELATIONSHIP OF THE QUINOLONE ANTIBACTERIALS AGAINST MYCOBACTERIA 2005-2008 Rs. 5,32,100
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR),  NEW DELHI, INDIA DEVELOPMENT OF NEW GENERATION QUINOLONE MOLECULES AGAINST MYCOBACTERIUM TUBERCULOSIS 2005-2008 Rs. 7,96,000
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR),  NEW DELHI, INDIA SYNTHESIS AND NEUROPHARMACOLOGY OF 4-AMINOBUTYRIC ACID ANALOGUES (CO-PI) 2005-2008 Rs. 8,96,000
INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR),  NEW DELHI, INDIA DESIGN AND SYNTHESIS OF NOVEL NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF AIDS AND OPPORTUNISTIC INFECTIONS ASSOCIATED WITH AIDS INCLUDING TUBERCULOSIS 2006-2009 Rs. 10,00,000

 
DEPARTMENT OF BIOTECHNOLOGY (DBT),  NEW DELHI, INDIA VIRTUAL CENTRE OF EXCELLENCE IN TUBERCULOSIS RESEARCH 2007-2012 Rs. 39,56,000

(TOTAL: Rs. 10.0667 Crore)

 

IN COLLABORATION WITH INDIAN INSTITUTE OF SCIENCE, Bangalore

&  THE FOUNDATION FOR MEDICAL RESEARCH, Mumbai

 

Research Students Guided / Guiding:

Ph.D. Thesis : 

1.      Mr. R. Thirumurugan (CSIR Senior Research Fellow) : “DESIGN AND SYNTHESIS OF DISUBSTITUTED ARYL SEMICARBAZONES AND ITS ANALOGUES AS ANTICONVULSANTS”-Completed

2.      Ms. Tanushree R. Bal (CSIR Senior Research Fellow) : “DESIGN AND SYNTHESIS OF AMINOPYRIMIDINIMINO ISATIN ANALOGUES AS NOVEL NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF AIDS” -Completed

3.    Mr. M. Dinakar (UGC Project Fellow): "DEVELOPMENT OF NEWER FUSED QUINOLONE MOLECULES AGAINST MYCOBACTERIUM TUBERCULOSIS"-Guiding

4. Mr. Senthil Kumar (CSIR Senior Research Fellow): "INVESTIGATION ON STRUCTURE-ACTIVITY RELATIONSHIP OF QUINOLONE DERIVATIVES AGAINST MYCOBACTERIA"-Guiding

5. Ms. Debjani Banerjee (ICMR Senior Research Fellow): "ISATIN-β-THIOSEMICARBAZONES AS NON-NUCLEOSIDE HIV-1 REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF AIDS AND OPPORTUNISTIC INFECTIONS ASSOCIATED WITH AIDS" -Guiding

6. Ms. Purna Nageswari (Lecturer, BITS, Pilani): "ISOCITRATE LYASE ENZYME AS TARGET IN PERSISTANT MYCOBACTERIAL TUBERCULOSIS INFECTION: SYNTHESIS OF 2-ARYLTHIAZOLIDINE-4-CARBOXYLIC ACID DERIVATIVES AND ITS ANTIMYCOBACTERIAL EVALUATION "-Guiding

7. Mr. Thimmappa (DBT Senior Research Fellow):

 

 

M.Pharm Projects : More than 40

B.Pharm Projects: More than 55

     

List of Significant Publications

PUBLISHED PAPERS

2008

1. R.R. Kumar, S. Perumal, P. Senthilkumar, P. Yogeeswari, D. Sriram, Discovery of antimycobacterial spiro-piperidin-4-ones: an atom economic, stereoselective synthesis, and biological intervention, J. Med. Chem. 51, 5731-5735, 2008.
2. R.R. Kumar, S. Perumal, P. Senthilkumar, P. Yogeeswari, D. Sriram, A highly atom economic , chemo-, regio-, and steroselective synthesis, and discovery of spiro-pyrido-pyrrozolines and pyrrolidines as animycobacterial agents, Tetrahedron, 64, 2962-2971, 2008.
3. P. Yogeeswari, J.V. Ragavendran, D. Sriram, R. Kavya, K. Vanitha, H. Neelakantan, Newer N-phthaloyl GABA derivatives with antiallodynic and antihyperalgesic activities in both sciatic nerve and spinal nerve ligation models of neuropathic pain, Pharmacology., 81, 21-31, 2008.
4. M. Dinakaran, P. Senthilkumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram, Synthesis, antimycobacterial activities and phototoxic evaluation of 5H-thiazolo[3,2-a]quinoline-4-carboxylic acid derivatives, Med. Chem. 4, 482-491, 2008.
5. M. Dinakaran, P. Senthilkumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram, Novel ofloxacin derivatives: synthesis, antimycobacterial and toxicological evaluation, Bioorg. Med. Chem. Lett., 18, 1229-1236, 2008.
6. D. Sriram, P. Yogeeswari, M. Dinakaran, M. Sowmya, Synthesis, anti-HIV and antitubercular activities of nelfinavir diester derivatives, Biomed. Pharmacother., 62, 1-5, 2008.

7. M. Dinakaran, P. Senthil Kumar, P. Yogeeswari, . China, V. Nagaraja, D. Sriram, Antimycobacterial and phototoxic evaluation of novel 6-fluoro/nitro-4-oxo-7-(sub)-4H-1,3-thiazeto[3,2-a]quinoline-3-carboxylic acid, International J. Antimicrob. Chemother., 31, 337-344, 2008
8. P. Senthil Kumar, M. Dinakaran, Debjani Banerjee, R.V. Devakaram, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram, Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids, Bioorg. Med. Chem., 16, 2558-2569, 2008.

9. M. Dinakaran, P. Senthil Kumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram,  Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid, Bioorg. Med. Chem., 16, 3408-3418, 2008.

10. L. Sebastian, A. Desai, M.N. Shampur, P. Yogeeswari, D. Sriram, Vasanthapuram R, N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo, Virol. J., 5:64, 2008.

6. D. Sriram, P. Yogeeswari, D.Y. Priya, Antimycobacterial activity of novel N-(substituted)-2-isonicotinoylhydrazino carbothioamade endowed with high activitytowards INH-resistant tuberculosis, Biomed. Pharmacother., In Press, 2008.

7. J. Vaigunda Ragavendran, D. Sriram, S. Kotapati, J. Stables, P. Yogeeswari, Newer GABA Derivatives for the Treatment of Epilepsy Including Febrile Seizures: A  Bioisosteric Approach, Eur. J. Med. Chem., In Press, 2008.

 

2007

1. P. Yogeeswari, J. Vaigunda Ragavendran, D. Sriram, Y. Nageswari, R. Kavya, N. Sreevatsan, K. Vanitha, J. Stables, Discovery of 4-Aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: A Hybrid pharmacophore approach, J. Med. Chem. 50, 2459-2467, 2007.
2. D. Sriram, P. Senthilkumar, M. Dinakaran, P. Yogeeswari, A. China, V. Nagaraja, Antimycobacterial Activities of Novel 1-(Cyclopropyl/tert-butyl/4-fluorophenyl)-1,4-dihydro- 6-nitro-4-oxo-7-(substituted secondary amino)-1,8-naphthyridine-3-carboxylic Acid, J. Med. Chem. 50, 6232-6239, 2007.
3. D. Sriram, P. Yogeeswari, M. Dinakaran, R. Thirumurugan, Antimycobacterial activity of novel 1-(5-cyclobutyl-1,3-oxazol-2-yl)-3-(sub)phenyl/pyridylthiourea endowed with high activity toward multi-drug resistant tuberculosis, J. Antimicrob. Chemother., 59, 1194-1196, 2007.
4. D. Sriram, P. Yogeeswari, Prathiba Dakhla, P. Senthil Kumar, Debjani Banerjee, N-Hydroxythiosemicarbazones: Synthesis and in-vitro antitubercular activity, Bioorg. Med. Chem. Lett., 17, 1888-1893, 2007.
5. D. Banerjee, T.R. Bal, P. Yogeeswari, D. Sriram, L. Sebastin, A. Desai, S.N. Madhusudhana, V. Ravi, Isatin derivatives inhibit Japanese encephalitis virus entry and replication in-vitro, Med. Chem. Res., 15, 133-135, 2007.
6. P. Yogeeswari, D. Sriram, P. Sahitya, J.V. Ragavendran, V. Ranganadh, Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: A Pharmacophoric hybrid approach, Bioorg. Med. Chem. Lett., 17, 3712-3715, 2007.
7. Shalini, P. Yogeeswari, D. Sriram, S. Induja, Microwave-assisted Synthesis, Anticonvulsant activity and Quantum Mechanical modeling of N-(4-Bromo-3-methylphenyl)semicarbazones, J. Zhejiang Univ. Section B (Springer), 8, 45-55, 2007.
8. J. V. Ragavendran, D. Sriram, S.K. Patel, I. Vikram Reddy, N. Bharathwajan, J. Stables, P. Yogeeswari, Design and Synthesis of Anticonvulsants from a Combined Phthalimide-GABA –Anilide and Hydrazone Pharmacophore, Eur. J. Med. Chem., 42, 146-151, 2007.
9. P. Yogeeswari, J.V. Ragavendran, D. Sriram, Neuropathic pain: Strategies in drug discovery and treatment, Expert Opinion on Drug Discovery, 2, 169-184, 2007.
10. K.N. Purna, P. Dhakla, P. Senthil Kumar, P. Yogeeswari, D. Sriram, 5-Nitro-2-furaldehyde thiosemicarbazones: Synthesis and in-vitro antimycobacterial activities, Med. Chem. Res., 15, 223-224, 2007.
11. N.M. Ragavendra, P. Thampi, P.M. Gurubasavarajaswamy, D. Sriram, Synthesis, Antitubercular and Anticancer Activities of Substituted Furyl-quinazolin-3(4H)-ones, Arch. Pharm.(Weinheim), 340, 635-641, 2007.
12. M. Dinakaran, C. Yogesh, P. Yogeeswari, D. Sriram, Synthesis of various 7-substituted-1-t-butyl-1,4-dihydro-8-methyl-6-nitro-4-oxo quiniline-3-carboxylic acid, Med. Chem. Res., 15, 328, 2007.
13. N.M. Ragavendra, P. Thampi, P.M. Gurubasavarajaswamy, D. Sriram, Synthesis and antimicrobial activities of some novel substituted 2-imidazolyl-N-(4-oxo-quinazolin-3(4H)-yl)-acetamides, Chem. Pharm. Bull., 55, 1615-1619, 2007.
14. D. Sriram, P. Yogeeswari, G. Senchani, D. Banerjee, Newer Tetracycline derivatives: Synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase, Bioorg. Med. Chem. Lett., 17, 2372-2375, 2007.
15. J.V. Ragavendran, I. Vikram Reddy, P. Yogeeswari, D. Sriram, Synthesis of 4-{[(3Z)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]amino}-N-substituted phenyl) butanamides possessing antiallodynic and antihyperalgersic activities in two rat models of neuropathic pain, Med. Chem. Res., 15, 225-226, 2007.
17. A.S.K. Reddy,  J.V. Ragavendran, P. Yogeeswari, D. Sriram, Pharmacological screening of candidate anticonvulsants in the animal model of febrile seizures, Med. Chem. Res., 15, 285-286, 2007.
18. P. Senthil Kumar, M. Dinakaran, P. Yogeeswari, D. Sriram, Synthesis and antitubercular activities of 1-(cyclopropyl/t-butyl/4-fluorophenyl)-1,4-dihydro-6-nitro-4-oxo-7-(substituted secondary amines)-1,8-naphthyridine-3-carboxylic acid, Med. Chem. Res., 15, 281-282, 2007.
19. R.R. Kumar, S. Perumal, P. Senthilkumar, P. Yogeeswari, D. Sriram, An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles, Bioorg. Med. Chem. Lett., 17, 6459-6462, 2007.
20. D. Sriram, P. Yogeeswari, N. Raveendra Babu, K.N. Purna, Synthesis and in-vitro anti-HIV activities of Didanosine prodrugs, J. Enzyme Inhib. Med. Chem., 22, 51-55, 2007.
21. M. Shalini, P. Yogeeswari, D. Sriram, J.P. Stables, Cyclization of the semicarbazone template of aryl semicarbazones: Synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one, Biomed. Pharmacother., In Press, 2007.
22. D. Sriram, Debjanai Banerjee, P. Yogeeswari, Efavirenz Mannich bases: Synthesis, anti-HIV and anitubercular activities, J. Enzyme Inhib. Med. Chem., In Press, 2007.
23. P. Senthil Kumar, M. Dinakaran, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram, Antimycobacterial activities of novel fluoroquinolones, Biomed. Pharmacother., In Press, 2007.
24. M. Dinakaran, P. Senthil Kumar, P. Yogeeswari, D. Sriram, Antitubercular activities of novel benzothiazolo naphthyridone carboxylic acid derivatives endowed with high activity toward multi-drug resistant tuberculosis, Biomed. Pharmacother., In Press, 2007.

 

2006

1. D. Sriram, P. Yogeeswari, R. Thirumurugan, P. Roheeth Kumar, Discovery of Newer Antitubercular Oxazolyl thiosemicarbazones, J. Med. Chem., 49, 3448-3450, 2006.
2. P. Yogeeswari, J.V. Ragavendran, D. Sriram, An Update on GABA Analogs for CNS Drug Discovery, Recent Patent on CNS Drug Discov.,  Vol 1 (First issue) 113-118, 2006.
3. P. Yogeeswari, D. Sriram, J. Vaigunda Raghavendran, R. Thirumurugan, S. Induja, J.P. Stables, Synthesis and structure-activity relationship on anticonvulsant aryl semicarbazones, Med. Chem., 2, 55-62, 2006.
4. D. Sriram, P. Yogeeswari, K. Madhu, Synthesis and in-vitro antitubercular activity of some
1-[(4-sub)phenyl]- 3-(4-{1-[(pyridine-4-carbonyl)hydrazono]ethyl phenyl) thiourea, Bioorg. Med. Chem. Lett. 16, 876-878, 2006.
5. R. Thirumurugan, D. Sriram,  J.P. Stables, P. Yogeeswari, 2,4-Dimethoxyphenyl semicarbazones with anticonvulsant activity against three animal models of seizure: Synthesis and Pharmacological evaluation, Bioorg. Med. Chem., 14, 3106-3112, 2006.

6. D. Sriram, P. Yogeeswari, R.V. Devakaram, Synthesis, in vitro and in vivo antimycobacterial activities of diclofenac acid hydrazones and amides, Bioorg. Med. Chem., 14, 3113-3118, 2006.

7. D. Sriram, P. Yogeeswari, S.P. Reddy, Synthesis of Pyrazinamide Mannich bases and its antitubercular properties,  Bioorg. Med. Chem. Lett., 16, 2113-2116, 2006.

8. D. Sriram, P. Yogeeswari, N.S. Myneedu, V. Saraswat, Abacavir prodrugs: Microwave-assisted synthesis and their evaluation of anti-HIV activities, Bioorg. Med. Chem. Lett., 16, 2127-2129, 2006.
9. D. Sriram, A. Aubry, P. Yogeeswari, L.M. Fischer, Gatifloxacin derivatives: Synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis DNA gyrase, Bioorg. Med. Chem. Lett., 16, 2982-2985, 2006.
10. P. Yogeeswari, D. Sriram, R.Thirumurugan, T. R. Bal, Epibatidine and its analogues as nicotinic acetylcholine receptor agonist: An update. Nat. Prod. Res., 20, 497-505, 2006.

11. D. Sriram, P. Yogeeswari, K. Meena, Design, synthesis, anti-HIV and antitubercular activities of isatin derivatives, Pharmazie, 61, 271-274, 2006.

12. P. Yogeeswari, R.Thirumurugan, D. Sriram,  L.R.J. Suniljit, J. Vaigunda Ragavendran, R. Kavya, K. Rakhra, J.P. Stables, Synthesis of some new semicarbazone derivatives as anticonvulsants with GABA- mediated mechanism, Acta Pharm., 56, 259-272, 2006.
13. M. Shaharyar, A.A. Siddiqui, M. Asharaf Ali, D. Sriram, P. Yogeeswari, Synthesis and in-vitro antimycobacterial activity of N1-Nicotinoyl-3-(4’-hydroxy-3’-methyl phenyl)-5-[(sub)phenyl]-2-pyrazolines, Bioorg. Med. Chem. Lett., 16, 3947-3949, 2006.
14. D. Sriram, T. R. Bal, P. Yogeeswari, D.R. Radha, V. Nagaraja, Evaluation of antimycobacterial and DNA gyrase inhibition of fluoroquinolone derivatives, J. Gen. App. Microbiol., 52, 195-200, 2006.
15. S. Mehta, P. Yogeeswari, Roheeth Kumar, D. Sriram, J.Stables, Heteroaryl-substituted semicarbazones: Synthesis and anticonvulsant activity of N-(3-Methylpyridin-2-yl)-substituted semicarbazones, J. Het. Chem., 43, 1287-1293, 2006.
16. Shalini, P. Yogeeswari, D. Sriram, P. Kudyar, P. Roheeth Kumar, S. Induja, J.P. Stables, Quantum Mechanical Modeling of N4-(2, 5-Disubstituted phenyl) Semicarbazones: Synthesis and Anticonvulsant Activity of N4-(2, 5-dimethylphenyl/-2-fluoro-5-methyl phenyl) Semicarbazones, Med. Chem., 2, 617-626, 2006.
17. D. Sriram, P. Yogeeswari, M.R.K Kishore, Synthesis and anti-HIV activity of nevirapine prodrugs, Pharmazie, 61, 895-897, 2006.
18. M. Shaharyar, M. Asharaf Ali, D. Sriram, P. Yogeeswari, Synthesis and antimicrobial activity of 3-(4'-Hydroxy-3'methylphenyl)-5-[(substituted)phenyl]-4,5-dihydro-1H-1-pyrazolyl-4-pyridylmethanone derivatives, Acta Pol. Pharm. -Drug Res., 63, 491-496, 2006.

 

2005

1. P. Yogeeswari, D. Sriram, R. Thirumurugan, J.V. Raghavendran, K. Sudhan, P. Roheeth Kumar, J. Stables, Discovery of N-(2,6-Dimethylphenyl) substituted Semicarbazones as Anticonvulsants : Hybrid Pharmacophore-based design, J. Med. Chem., 48, 6202-6211, 2005.

2. D. Sriram, T. R. Bal, P. Yogeeswari, Aminopyrimidinimino isatin analogues: Design and synthesis of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum anti-microbial properties, Med. Chem., 1, 277-285, 2005.

3. D. Sriram, T. R. Bal, P. Yogeeswari, Newer aminopyrimidinimino isatin analogues as non-nucleoside HIV-1 reverse transcriptase inhibitors for HIV and other opportunistic infections of AIDS: Design, synthesis and biological evaluation, Farmaco, 60, 377-384, 2005.

4. P. Yogeeswari, D. Sriram, J.V. Raghavendran, R. Thirumurugan, The GABA shunt: An attractive and potential therapeutic target in the treatment of epileptic disorders, Curr. Drug Metabolism, 6, 127-140, 2005.

5. D. Sriram, P.Yogeeswari, A.N. Nagappa, Combinatorial Synthesis of anti-HIV-1 agents, Comb. Chem. High Throughput Screen., 8(6), 377-385, 2005.

6. D. Sriram, P. Yogeeswari, R.Thirumurugan, T. R. Bal, Camptothecin and its analogues: A review on their chemotherapeutic potential. Nat. Prod. Res., 19, 393-412, 2005.

7. P.Yogeeswari, D. Sriram, V.Veena, R.Kavya, K.Rakhra, S.Mehta, J.VaigundaRagavendran, R.Thirumurugan, J.P.Stables, Synthesis of Novel Aryl semicarbazones as Potential Anticonvulsant Agents, Biomed. Pharmacother., 59, 51-55, 2005.

8. P. Yogeeswari, D. Sriram, S. Mehta, D. Nigam, M. Mohan Kumar, S. Murugesan, J.P. Stables, Anticonvulsant and neurotoxicity evaluation of some 6-substituted benzothiazolyl-2-thiosemicarbazones, Farmaco, 60 (1), 1-5, 2005.

9. P. Yogeeswari and D. Sriram, Betulinic acid and its derivatives: A review on their biological properties, Curr. Med. Chem., 12 (3), 763-771, 2005.
10. D. Sriram, P. Yogeeswari, J.S. Basha, D. R. Radha, V. Nagaraja, Synthesis and Antimycobacterial evaluation of various 7- Substituted Ciprofloxacin Derivatives, Bioorg. Med. Chem., 13, 5774-5778, 2005.
11. D. Sriram, P. Yogeewari and K. Madhu, Synthesis and in-vitro antimycobacterial activity of some isonicotinyl hydrazones, Bioorg. Med. Chem. Lett., 15, 4502-4505, 2005.
12. T.R. Bal, B. Anand, P. Yogeeswari, D. Sriram, Synthesis and evaluation of anti-HIV activity of isatin b-thiosemicarbazone derivatives, Bioorg. Med. Chem. Lett., 15, 4451-4455, 2005.
13. D. Sriram, P. Yogeeswari, T.G. Ashok Kumar, Microwave-assisted synthesis, and anti-YFV activity of 2, 3-diaryl-1, 3-thiazolidin-4-ones, J. Pharm. Pharm. Sci., 8, 429-466, 2005.
14. D. Sriram, P. Yogeeswari, N. Srichakravarthy, T. R. Bal, Synthesis of zidovudine prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS, Biomed. Pharmacother. 59, 452-455, 2005.
15. D. Sriram, P. Yogeeswari, N. Srichakravarthy, T. R. Bal, Nevirapine derivatives with broad spectrum chemotherapeutic properties for the effective treatment of HIV / AIDS, Biomed. Pharmacother., 59, 456-459, 2005.
16. D. Sriram, P. Yogeeswari, T.G. Ashok Kumar, Microwave-assisted synthesis, anti-HIV activity of 2, 3-diaryl-1, 3-thiazolidin-4-ones, Ind. J. Pharm. Sci., 67, 496-499, 2005.
17. D. Sriram, P. Yogeeswari, T.G. Ashok Kumar, Microwave Assisted Synthesis, Anti-HIV, and Anti-YFV Activities of Schiff Bases of N-Hydroxy-N1-Aminoguanidine tosylate, Ind. J. Pharm. Sci., 67, 493-496, 2005..
18. D. Sriram, T. R. Bal, P. Yogeeswari, Aminopyrimidinimino isatin analogues: Design of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties, J. Pharm. Pharm. Sci., 8, 565-577, 2005.

19. P. Yogeeswari, D. Sriram, R. Kavya, S. Tiwari, Synthesis and in-vitro cytotoxicity evaluation of gatifloxacin Mannich bases, Biomed. Pharmacother.,  59, 501-510, 2005.

20. D. Sriram, P. Yogeeswari, Gayatri Gopal, Synthesis, anti-HIV and antitubercular activities of lamivudine prodrugs, Eur. J. Med. Chem., 40, 1373-1376, 2005. "Ranked 11th In the Science Direct TOP 25 HOTTEST ARTICLES"
21. D. Sriram, T. R. Bal, P. Yogeeswari, Design, synthesis and biological evaluation of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum antimicrobial properties: Aminopyrimidinimino isatin analogues, Med. Chem. Res., 14, 211-228, 2005.

2004

1. D. Sriram, V. S. Rao, K. V. G. Chandrasekhar and P. Yogeeswari, Progress in the research of artemisinin and its analogues as anti-malarials: an update, Nat. Prod. Res., 18(6), 503-527, 2004.

2. D. Sriram, T. R. Bal, P. Yogeeswari, Design, synthesis and biological evaluation of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties, Bioorg. Med. Chem., 12, 5865-5873, 2004.

3. P.Yogeeswari, J. Vaigunda Raghavendran, R. Thirumurugan, A. Saxena, D. Sriram, Ion channels as important targets for antiepileptic drug design, Curr. Drug Targets, 5, 589-602, 2004.

4. D. Sriram, P. Yogeeswari, R. Thirumurugan, Antituberculous activity of some aryl semicarbazones derivatives, Bioorg. Med. Chem. Lett., 15, 3923-3924, 2004.

5. P. Yogeeswari, D. Sriram, S.N. Pandeya, J.P. Stables, 4-Sulphamoylphenyl semicarbazones with anticonvulsant activity, Farmaco, 59, 609-613, 2004.

6. P. Yogeeswari, R. Thirumurugan, R. Kavya, J. Selwyn Samuel, J.P. Stables, D. Sriram, 3-Chlorophenyl, 2-methyl-substituted semicarbazones: Synthesis and anticonvulsant activity, Eur. J. Med. Chem., 39, 729-734, 2004."Ranked 15th In the Science Direct TOP 25 HOTTEST ARTICLES"

7. D. Sriram, K. Jyothi Mallika and P. Yogeeswari, Synthesis of Tetrahydro-2H-[1, 3, 5] thiadiazine-5-(4-pyridylcarboxamido)-2-thione with antitubercular activity, Sci. Pharm., 75, 35-41, 2004.

8. D. Sriram, P. Yogeeeswari, N. Srichakravarthy, Tanushree Ratan Bal, Synthesis of Stavudine Amino acid Ester Prodrugs with Broad-Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV/AIDS, Bioorg. Med. Chem. Lett., 14, 1085-1087, 2004.

    2002-2003

1. P.Yogeeswari, D. Sriram, A.Brahmandam, I.Sridharan, R.Thirumurugan and J.P. Stables, Synthesis of novel aryl semicarbazones as anticonvulsants with GABA-mediated mechanism, Med. Chem. Res., 12(2), 57-68, 2003.

2. P.Yogeeswari, D. Sriram, V.Saraswat, J.Vaigunda Ragavendran, M.Mohan Kumar, S.Murugesan, R.Thirumurugan, J.P.Stables, Synthesis and Anticonvulsant and Neurotoxicity Evaluation of N4 –Phthalimido Phenyl (Thio) Semicarbazides, Eur. J. Pharm. Sci., 20, 341-346, 2003.

3. D. Sriram, P.Yogeeswari, Towards the Design and Development of Agents with Broad Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV / AIDS, Curr. Med. Chem., 10, 1909-1915, 2003.

4. S.N.Pandeya, P.Yogeeswari, D. Sriram, G.Nath; Synthesis, Antibacterial and antifungal activities of N-Mannich bases of 3-[N2-pyrimethaminylimino] isatin, Ind. J. Pharm. Sci., 64, 209-212, 2002.

5. D. Sriram, P.Yogeeswari, S.N.Pandeya, S. Ananthan; Antituberculous activity of isatin derivatives, Sci. Pharm., 70, 73-79, 2002.

6. P.Yogeeswari, D. Sriram, L.R.J. Suniljit, S.S.Kumar, J.P.Stables; Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones, Eur. J. Med. Chem., 37, 231-236, 2002.

    2000-2001

1. S.N. Pandeya, D. Sriram, P.Yogeeswari, S. Ananthan; Antituberculous activity of Norfloxacin Mannich bases with Isatin derivatives, Chemotherapy, 47, 266-269, 2001.

2. S.N.Pandeya, D. Sriram, P.Yogeeswari, J.P. Stables; Anticonvulsant and Neurotoxicity evaluation of 5-(un)-substituted isatinimino derivatives, Pharmazie, 56, 875-878, 2001.

3. V. Alagarsamy, U.S. Pathak, D. Sriram, S.N. Pandeya, E. De Clercq; Anti-HIV and antibacterial activities of some disubstituted quinazolones and their Bio-isostere Disubstituted thienopyrimidones; Ind. J.Pharm Sci. 62(6), 433-437, 2000.

4. S.N. Pandeya, D. Sriram, G. Nath, E. De Clercq; Synthesis, antibacterial, antifungal and anti-HIV activity of Schiff and Mannich bases of Isatin with N- [6-chlorobenzothiazol-2-yl] thiosemicarbazide. Ind. J. Pharm Sci. 61(6). 358-361, 2000.

5. S.N. Pandeya, D. Sriram, G.Nath, E.De Clercq; Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of Isatin and its derivatives with Triazole, Arzneim-Forsch./Drug Res. 50(1), 55-59, 2000.

6. S.N. Pandeya, D. Sriram, G. Nath, E.De Clercq; Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin Mannich bases, Eur, J. Med. Chem. 35, 249-265, 2000.

1998-1999

1. S.N.Pandeya,  D. Sriram, G.Nath, E.De Clercq; Synthesis and antimicrobial activity of Schiff and Mannich bases of Isatin and its derivatives with pyrimidine, Farmaco, 54, 624-628, 1999.

2. S.N. Pandeya, P.Yogeeswari, D. Sriram, E. De Clercq, C. Pannecouque, M. Witvrouw; Synthesis and Screening for Anti-HIV activity of some N-Mannich bases of isatin derivatives, Chemotherapy, 45, 192-196, 1999.

3. S.N. Pandeya, D. Sriram, G.Nath, E.De Clercq; Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methyl mercapto quinazolin –4(3H)- one. Pharm. Act. Helv., 74, 11-17, 1999.

4. S.N. Pandeya, D. Sriram, G.Nath, E.De Clercq; Synthesis, antibacterial, antifungal and anti-HIV evaluation of Norfloxacin Mannich bases, Sci. Pharm. 67, 103-111, 1999.

5. S.N. Pandeya, D. Sriram, G. Nath, E.De Clercq; Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4’-Chlorophenyl) thiazol-2-yl] thiosemicarbazide, Eur. J. Pharm. Sci. 9, 25-31, 1999.

6. S.N.Pandeya, D. Sriram, V.Alagarsamy; Synthesis and evaluation of some novel Schiff’s and Mannich bases of Indole-2,3-diones as potential antibacterial, analgesic and anti-inflammatory agents. Acta Pharm. Turc. XLI(4), 153-158, 1999.

7. S.N.Pandeya, C.G.Sundari, N.Mariammal, P.Saravanan, S.S. Balaji, R.S.Kumar, D. Sriram; Synthesis and antibacterial activity of Mannich bases of Ciprofloxacin and Lomefloxacin with Isatin and its derivative, Ind. J. Pharm. Sci. 60(5), 280-282, 1998.

8. S.N.Pandeya, D. Sriram; Synthesis and screening for antibacterial activity of Schiff’s and Mannich bases of Isatin and its derivatives, Acta Pharm. Turc. 40(10), 33-38, 1998.

9. S.N.Pandeya, P.Yogeeswari, D. Sriram, G.Nath; Synthesis and antimicrobial activity of N-Mannich bases of 3-[N’-sulphadoximino] Isatin and its methyl derivative, Boll. Chim. Farm. 137(8), 321-324, 1998.
10. S.N. Pandeya, D. Sriram, E. De Clercq; C. Pannecouque, M. Witvrouw; Anti-HIV activity of some Mannich bases of isatin derivatives, Ind. J. Pharm. Sci. 60(4), 207-212, 1998.

 

Expert Reviewer for the following journals

1. Bioorganic  Medicinal Chemistry (Elsevier)

2. Bioorganic  Medicinal Chemistry Letters (Elsevier)

3. Letters in Drug Design & Discovery (Bentham)

4. Combinatorial Chemistry & High Throughput Screening (Bentham)

5. Current Enzyme Inhibition (Bentham)

6. Archives der Pharm. Pharm. Med. Chem.

7. Indian Journal of Chemistry, Section B (CSIR)

8. Recent Patents on Anti-infective drug discovery (Bentham)

9. Current Bioactive Agents (Bentham)

10. European Journal of Medicinal chemistry (Elsevier)

11. Journal of Medicinal Chemistry  (ACS)

 

BOOK

 

 

 

Textbook on  Organic Medicinal Chemistry -

I edition  released in Jan 2007

 Publishers: Pearson Education Singapore Ltd.

www.pearsoned.co.in/dsriram

 

 

 

 

 

 

 

 

 

Academic Activities:

A. Courses Handled / Handling

1. Higher Degree Courses:    

Advanced Medicinal Chemistry

Chemistry of Natural Drugs and Macromolecules

Chemistry of Macromolecules

2. First Degree Courses

Pharmaceutical Analysis

Medicinal Chemistry

Chemistry of Synthetic drugs

Natural Drugs

Dispensing Pharmacy

Measurement Technique-I (Chemistry)

Microbiology Lab

 

      B. Member, Research Board, BITS, Pilani

      D. Doctoral Advisory Committee Member, BITS, Pilani 

Administrative Responsibilities:

Treasurer, Pharmaceutical Society, BITS-Pilani, Hyderabad Campus.

 

My Family

My Wife, Dr. P. Yogeeswari                                                                          Our Son, RAGHAV, Y.S.

 

And VAISHNAV, Y.S.

 

My Research Group

YOUNG PHARMACY TEACHER OF THE YEAR 2006-

AWARDED BY APTI-PRESENTED BY UNIOIN

 MINISTER OF STATE FOR PLANNING

MR. M.V. RAJASEKARAN

 

           Last updated 27th November 2008

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