Orianna Webb's music has been hailed as "abound[ing] in urgent and mysterious detail" (Cleveland Plain Dealer) and as "work of uncompromising energy, both rhythmically athletic and sensuously lyrical" (Cleveland Free Times). Webb is a native of Akron, Ohio and is currently in the Master of Music program in composition at the Cleveland Institute of Music (CIM). She earned a Bachelor of Arts in music with honors from the University of Chicago in 1997. Her teachers have included John Eaton, Roger Zahab, and, currently, Margaret Brouwer, and she has participated in masterclasses with Christopher Rouse, Donald Erb, Aaron Jay Kernis, Libby Larsen, Thea Musgrave, Bernard Rands, and Julian Anderson. In 1999 she attended the Summer Composition Program at La Schola Cantorum in Paris, France, where she studied with Samuel Adler, Philip Lasser, and Narcis Bonet.

Webb's piece Being and Becoming, commissioned by the Cleveland Orchestra Youth Orchestra, was premiered by that group in Severance Hall. Her piece Sequence Dreams for violin, marimba and glass instruments was commissioned by the Akron Art Museum. Webb received the 1999 Victor Herbert/ASCAP Award (First Place) and the 1999 Devora Nadworney Prize for Vocal Writing from the National Federation of Music Clubs as well as the 2000 Donald Erb Prize for Composition and the 1997 Olga and Paul Menn Foundation Prize for Composition. As a conductor, she has worked with the CIM New Music Ensemble and the University of Akron New Music Group/Daedalus, and has studied with Harold Farberman at the Conductors Institute at Bard. Webb teaches composition and music theory in the CIM Preparatory Division. She has served as Assistant Director of the CIM New Music Ensemble and, at the University of Chicago, co-founded the Undergraduate Composers' Concert Series. Orianna studied piano with Nicolas Constantinidis and Ethel Burke, and bassoon with Georgia Peeples.