USMLE Step 1
Although USMLE Step1 is designed to test the basic science
knowledge, many of the questions are in a clinical context. It is
important to bear that in mind when you read the manuals or when you
practice questions. Clinical relevant information is much more
likely to appear during the actual test.

About 25% of the questions are trivial (e.g. what enzyme is inhibited by
aspirin). You need to prepare for the rest of the questions. Although
you have to read a few thousand pages, Step1 is the easiest part of
the USMLEs. That is mainly because the available review materials are
very good and focused on what is actually tested.

Don't make the mistake of starting to read new textbooks.  That time is
much better spent if you just read the USMLE-focused review books
once more. You will find there around 85% of the information tested.
You have to rely on your long term memory for the other 15%.

However, keep a good textbook nearby for each subject. For reference
only. You will feel like reading more about certain topics. If you have
the software or internet version it is even better. That will save you
some search time. You might be able to access online textbooks from
home (through resources such as mdconsult.com).

Biochemistry, microbiology/immunology and pharmacology are
especially well covered by the review books. Learn them well and you
will know 95% of the questions in these areas. Anatomy, physiology,
behavioral sciences and pathology have review books that are very
well focused, but not as complete.

Practice test questions in between the readings. That will help you
focus and memorize the relevant topics. Leave 3-4 weeks in the end
so that you can go very quickly through all the information one more
time.

Schedule a few full-length test exams in the last few weeks so that you
get used to how to manage the time pressure. This will also help you
identify weak areas for the last minute review.

Work towards perfection, but don't become obsessed by it. You don't
have to answer all the questions right. There were at least 30
questions that I know I gave the wrong answer for, and that did not
have a major impact on my score. There is no way you could know all
the information tested. This time you have to depend on educated
guesses as well.